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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cell Signal. 2011 Oct 1;24(2):443–450. doi: 10.1016/j.cellsig.2011.09.022

Table 2.

Endogenous creatinine clearance rate (Ccr) and concentration of Ang II in plasma or renal tissue in different groups (n=6).

Day Ccr (mL/min/100 g) Concentration of Ang II
Plasma (pg/mL) Renal tissue (pg/mL/mg)
Control 14 1.16±0.37 270.5±92.8 861.2±107.5
28 1.13±0.42 300.74±88.7 798.2±97.5
Ang II 14 0.97±0.21 1026.25±148.2* 2438.7±179.8*
28 0.86±0.16 1022.3±132.7* 2326.4±136*
Telmisartan+ Ang II 14 0.83±0.11 1381.5±151.7* 2656.6±155.9*
28 1.07±0.15 1339.3±160.3* 2518.8±139.1*

Wistar rats received either vehicle (control), Ang II (400 ng/kg/min), or telmisartan (3 mg/kg/day)+Ang II (400 ng/kg/min) via mini-osmotic pumps for 14/28 days. Endogenous creatinine clearance rate (Ccr) and concentration of Ang II in plasma or renal tissue were measured on days 14 and 28.

*

p<0.05 compared with control group of respective duration.