Table 1.

Top association results carried forward to replication phase

SNP	Gene	Chr	Base-pair Position	MAF cases	MAF controls	P	Odds Ratio	95% Confidence Interval
rs4906902	GABRB3	15	24570861	0.14	0.22	3.6E-06	0.46	0.33 – 0.64
rs8192619	TAAR1	6	133008041	0.08	0.03	1.1E-05	3.76	2.08 – 6.78
rs7911	GBP1	1	89290708	0.41	0.32	1.1E-04	1.66	1.28 – 2.14
rs4234955	NPY1R	4	164479726	0.23	0.29	0.001	0.64	0.49 – 0.84
rs7537937	GBP2	1	89355278	0.36	0.30	0.001	1.53	1.18 – 1.98
rs10754261	GBP2	1	89363670	0.36	0.30	0.001	1.53	1.18 – 1.98
rs4453447	GABRB3	15	24554565	0.11	0.15	0.002	0.55	0.38 – 0.80
rs694066	GAL	11	68209561	0.06	0.09	0.002	0.47	0.30 – 0.76
rs10799897	RGS4	1	161309712	0.46	0.41	0.002	1.47	1.15 – 1.89
rs757228	GPX4	19	1052992	0.44	0.48	0.002	0.69	0.54 – 0.88
rs1329119	GBP2	1	89346614	0.34	0.28	0.003	1.48	1.14 – 1.92
rs4656093	GBP2	1	89344563	0.34	0.28	0.004	1.47	1.14 – 1.91
rs4656095	GBP2	1	89351396	0.34	0.28	0.004	1.47	1.14– 1.91
rs7154455	ESR2	14	63806413	0.33	0.30	0.005	1.43	1.12 – 1.84
rs2302109	GPX4	19	1061829	0.47	0.50	0.005	0.71	0.56 – 0.90
rs1256030	ESR2	14	63816923	0.45	0.49	0.007	0.73	0.59 – 0.92
rs6454674	CNR1	6	88929649	0.29	0.33	0.007	0.69	0.53 – 0.91
rs3783736	ESR2	14	63821125	0.42	0.39	0.007	1.38	1.09 – 1.74
rs1271572	ESR2	14	63831670	0.45	0.49	0.007	0.73	0.58 – 0.92
rs642544	GRIA4	11	105242230	0.38	0.43	0.009	0.72	0.57 – 0.92

Association results for top 20 ranked SNPs from the primary case/control study used to select genes for replication (SNPs that failed quality checks and ancestry-informative markers have been removed).

Abbreviations: Chr (chromosome), MAF cases (minor allele frequency in cases), MAF controls (minor allele frequency in controls).