Fig. 6. MicA expression in Y. pestis and functional consequences of its overexpression.
(A) Total RNA was isolated from the indicated Y. pestis strains and analyzed by Northen blot analysis using a MicA specific probe. (B) Either the empty vector or MicA-encoding plasmids were transformed into wild-type Y. pestis KIM5 and the levels of MicA transcript and OmpA protein levels in the resulting transformant strains were measured by primer extension and western analysis, respectively (α-HNS: loading control). (C) RAW 264.7 cells were infected with Y. pestis transformed with either empty vector or the MicA-encoding plasmids and analyzed as described in Fig. 1. One of three independent experiments is shown.