Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Microb Pathog. 2011 Oct 18;52(1):41–46. doi: 10.1016/j.micpath.2011.09.009

Fig. 7. Wild type Y. pestis out competes an isogenic ΔompA mutant in a mouse BSL2 model of pneumonic plague.

Fig. 7

Y. pestis KIM5 and the isogenic ΔompA mutant were mixed 1:1 and inoculated intranasally into groups of five C57BL/6 mice. Bacteria were recovered from the lungs, liver and spleen at 18 h, 36 h and 60 h post-infection. The competitive index (CI) was calculated as the ratio of the CFU of wild type Y. pestis to the CFU of the ΔompA mutant recovered from the lungs, liver and spleen of each mouse. Statistically significant reductions in organ colonization by the mutant strain are labeled by asterisks (paired t-test, P < 0.05).