Table 3.
Change in cortical thickness at the subtrochanteric area in patients with prolonged bisphosphonates treatment
| Measurements compared with baseline | 3.5 cm below greater trochanter | 4.0 cm below greater trochanter |
|---|---|---|
| Change in cortical thickness | ||
| Mean ± SD (mm) | −0.2 ± 0.5 | −0.2 ± 0.5 |
| Range (mm) | −1.8 to 0.9 | −1.1 to 1.3 |
| Increase (≥ 1 mm) | 0 (0%) | 2 (2.3%) |
| No change* | 80 (93.0%) | 83 (96.5%) |
| Decrease (≤ −1 mm) | 6 (7.0%) | 1 (1.2%) |
| Percent change of cortical thickness† | ||
| Mean ± SD (%) | −3.3 ± 9.2 | −2.9 ± 8.0 |
| Range (%) | −26.7 to 17.5 | −20.5 to 24.1 |
| Increase in cortical thickness > 20% | 0 (0%) | 1 (1.2%) |
| Increase between 5% to 20% | 15 (17.4%) | 9 (10.5%) |
| No change** | 37 (43.0%) | 36 (41.9%) |
| Decrease between −5% to −20% | 29 (33.7%) | 39 (45.3%) |
| Decrease in cortical thickness > 20% | 5 (5.8%) | 1 (1.2%) |
Values are expressed as number of patients; † percent change of cortical thickness = (change of cortical thickness/baseline cortical thickness) × 100; * no change is designated as the absolute difference between baseline and end cortical thickness less than 1 mm; ** no change is designated as the absolute percent change in cortical thickness less than 5%.