Table 3.
Prognostic hypoxia gene expression signatures in breast cancer
| Study | Description and size of gene signature | Hazard ratio (HR) | P-value |
|---|---|---|---|
| Chi et al. [65] | Signature of hypoxia upregulated genes in epithelial cells in vitro: 253 genes | MFS HR = 2.164 Death HR = 2.387 |
0.004 0.003 |
| Seigneuric et al. [67] | Early signature of hypoxia: 15 genes | DSS HR = NR | < 0.05 |
| Winter et al. [47] | Signature of hypoxia-related genes in HNSCC: 99 genes | NKI data set: MFS HR = 2.83 |
< 0.001 |
| Buffa et al. [63] | Common signature of hypoxia-related genes in HNSCC and breast cancer in vivo: 51 genes | NKI data set: MSF HR = 4.15 GSE2034 data set: RFS HR = 3.22 GSE3494 data set: DSS HR = 3.16 |
0.002 0.001 0.042 |
| Buffa et al. [103] | Reduced common signature of hypoxia-related genes in HNSCC and breast cancer: NK genes | NKI data set: MSF HR = 5.58 (NK = 3) GSE2034 data set: RFS HR = 4.15 (NK = 10) GSE3494 data set: DSS HR = 4.27 (NK = 2) |
< 0.001 < 0.001 0.006 |
DSS, disease-specific survival; GSE, genomic special event; MSF, metastasis-free survival; NK, number of genes; NKI, Netherlands Cancer Institute; NR, not reported; RFS, recurrence-free survival.