Table 1.
Differential reactivity against the three different MOG isoforms in samples with high-titer reactivity
| Percentage of samples tested (proportion)a | Monospecific (1 antigen only) | Oligospecific (2 antigens) | All 3 antigens | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| % | rhMOG118 (n) | rhMOG125 (n) | ratMOG125 (n) | % | rhMOG118 + rhMOG125 (n) |
rhMOG118 + ratMOG125 (n) |
rhMOG125 + ratMOG125 (n) |
rhMOG118, rhMOG125, ratMOG125 % (n) |
||
| HC | 10.4 (17/169) | 47.1 | 5 | 1 | 2 | 47.1 | 7 | 1 | 0 | 5.9 (1) |
| CIS | 7.3 (5/69) | 80.0 | 3 | 1 | 0 | 20.0 | 1 | 0 | 0 | 0 |
| MS | 6.8 (22/325) | 68.2 | 9 | 6 | 0 | 31.8 | 5 | 2 | 0 | 0 |
| RR-MS | 7.8 (15/192) | 66.7 | 6 | 4 | 0 | 33.3 | 4 | 1 | 0 | 0 |
| SP/PP-MS | 5.3 (7/133) | 71.4 | 3 | 2 | 0 | 28.6 | 1 | 1 | 0 | 0 |
Percentage of samples with identified high-titer reactivity to have high-titer reactivity exclusively to one MOG isoform, two of the MOG isoforms used or all three MOG isoforms, respectively. There are no significant differences between HC, CIS and MS or any of the MS subgroups (p > 0.05, χ2 test). Samples were deemed high-titer reactive, if the respective BR at the 1/800 serum dilution was above the defined cut-off BRs (5.8, 5.6, 9.4 for rhMOG118, rhMOG125 and ratMOG125).
a refer to additional file 2 for characteristics of all samples tested.