Table 2.
Cellular processes significantly changed in lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) by SNEA (Mann-Whitney p<0.001)
| Cellular process | Sub-network size | Median fold change | p-value |
|---|---|---|---|
| Adenocarcinoma | |||
| Wound healing | 385 | 1.02072 | 2.19 × 10-6 |
| ECM proteins | 571 | 1.0277 | 2.38 × 10-6 |
| Chromosome segregation | 149 | 1.10384 | 7.32 × 10-6 |
| Tissue remodeling | 168 | 1.05076 | 1.16 × 10-5 |
| Cell survival | 1251 | 1.03351 | 6.44 × 10-5 |
| Cell invasion | 486 | 1.02405 | 7.79 × 10-5 |
| Tissue invasion | 40 | 1.11402 | 1.23 × 10-4 |
| Mitotic cell cycle | 37 | 1.10189 | 2.31 × 10-4 |
| G2/M transition | 465 | 1.05898 | 2.37 × 10-4 |
| Abscission | 25 | 1.00683 | 2.82 × 10-4 |
| Oncogenesis | 347 | 1.02691 | 4.62 × 10-4 |
| Mitotic entry | 123 | 1.07766 | 4.95 × 10-4 |
| Centrosome separation | 38 | 1.13508 | 5.83 × 10-4 |
| Drug resistance | 244 | 1.04375 | 7.66 × 10-4 |
| Cell redox homeostasis | 18 | 1.12308 | 7.79 × 10-4 |
| Cell motility | 691 | 1.02671 | 7.94 × 10-4 |
| Mitotic checkpoint | 57 | 1.11636 | 8.92 × 10-4 |
| Cell contact | 929 | 1.02568 | 9.04 × 10-4 |
| Squamous cell carcinoma | |||
| Chromosome segregation | 149 | 1.1897 | 4.58 × 10-10 |
| Kinetochore assembly | 126 | 1.23986 | 7.28 × 10-10 |
| Mitosis | 924 | 1.05925 | 1.35 × 10-8 |
| Spindle assembly | 386 | 1.08566 | 6.70 × 10-8 |
| Cytokinesis | 291 | 1.05385 | 1.03 × 10-7 |
| ECM proteins | 571 | -1.02692 | 2.90 × 10-7 |
| Wound healing | 385 | -1.05074 | 2.44 × 10-6 |
| DNA replication initiation | 41 | 1.3792 | 1.02 × 10-5 |
| Mitotic checkpoint | 57 | 1.24069 | 1.03 × 10-5 |
| Cell invasion | 486 | -1.01081 | 1.20 × 10-5 |
| Mitotic spindle assembly | 41 | 1.23754 | 2.72 × 10-5 |
| G2/M transition | 465 | 1.05662 | 2.81 × 10-5 |
| Premeiotic DNA synthesis | 17 | 1.44176 | 3.11 × 10-5 |
| Cell motility | 691 | -1.01698 | 3.41 × 10-5 |
| Mitotic entry | 123 | 1.1247 | 3.64 × 10-5 |
| Drug resistance | 244 | 1.01383 | 4.29 × 10-5 |
| DNA replication checkpoint | 40 | 1.35065 | 5.73 × 10-5 |
| Genome instability | 178 | 1.13299 | 7.80 × 10-5 |
| S phase | 737 | 1.02773 | 2.19 × 10-4 |
| DNA unwinding | 117 | 1.15665 | 2.39 × 10-4 |
| Tissue remodeling | 168 | -1.03451 | 3.11 × 10-4 |
| Chromosome condensation | 174 | 1.05662 | 3.14 × 10-4 |
| Cell growth | 2072 | 1.00691 | 3.18 × 10-4 |
| Centrosome separation | 38 | 1.30654 | 4.21 × 10-4 |
| Translation | 689 | -1.01232 | 4.53 × 10-4 |
| Cell division | 598 | 1.00883 | 4.69 × 10-4 |
| Chemosensitivity | 129 | 1.03154 | 4.94 × 10-4 |
| Cell–cell contact | 307 | -1.04502 | 5.89 × 10-4 |
| rRNA processing | 69 | 1.21023 | 6.52 × 10-4 |