Table 3. Clinical parameters at diagnosis of CML patients in chronic phase expressing normal and elevated levels of MDR1 gene.
| Parameter | MDR1(+) patients | MDR1(–) patients | P |
|---|---|---|---|
| Patients [n=] | 48 [49.5%] | 49 [50.5%] | |
| Age | |||
| Mean ± SD [years] | 52.4±15.4 | 48.7±12.6 | NS |
| Patients | |||
| ≤60 years [n=] | 24/34 [71%] | 10/34 [29%] | 0.008 |
| ≤60 years [n=] | 24/63 [38%] | 39/63 [62%] | |
| Gender | |||
| Males [n=] | 27 [56%] | 32 [65%] | NS |
| Females [n=] | 21 [44%] | 17 [35%] | |
| BCR-ABL transcripts | |||
| b3a2 [n=] | 25 [52%] | 28 [57%] | NS |
| b2a2 [n=] | 23 [48%] | 21 [43%] | |
| WBC | |||
| Mean ± SD [×109/L] | 105.5±79.8 | 143.6±96.5 | 0.047 |
| Platelets | |||
| Mean ± SD [×109/L] | 647.2±447.8 | 591.0±381.4 | NS |
| Hemoglobin | |||
| Mean ± SD | 110.6±38.6 | 112.4±17.2 | NS |