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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Arch Biochem Biophys. 2011 Mar 21;509(2):117–126. doi: 10.1016/j.abb.2011.03.006

Figure 1.

Figure 1

In pyruvate carboxylase, reaction (1) occurs at the biotin carboxylation (BC) domain and involves the ATP-dependent activation of bicarbonate to form a putative carboxyphosphate intermediate, from which the enzymic biotin is then carboxylated to form the enzyme-carboxybiotin complex. The carboxybiotin on the biotin carboxyl carrier protein (BCCP) domain then moves to the carboxyl transfer (CT) domain of its partner subunit where the carboxy group is transferred to pyruvate to form oxaloacetate in reaction (2).