Table 4.
Significant gray matter atrophy in patients with frontotemporal lobar degeneration and significant association of non-fluent speech (words per minute) with gray matter atrophy
| Anatomic Locus (Brodmann Area) | Coordinates | Z-Score | Cluster Size (Voxels) | ||
|---|---|---|---|---|---|
| X | Y | Z | |||
| Gray Matter Atrophy Relative to Controls | |||||
| PNFA | |||||
| L inferior frontal/insula (44) | −40 | −11 | 12 | 4.46 | 350 |
| L inferior frontal (11) | −30 | 46 | −9 | 3.87 | 269 |
| L superior occipital (19) | −34 | −80 | 32 | 3.97 | 192 |
| SemD | |||||
| L inferior temporal (38/20/21) | −28 | −7 | −22 | 5.53 | 6446 |
| L inferior frontal/insula (6) | −42 | −13 | 12 | 4.29 | 175 |
| R inferior temporal (38/20/21) | 28 | −5 | −22 | 5.01 | 2806 |
| SOC/EXEC | |||||
| L superior frontal (9) | −8 | 42 | 15 | 4.42 | 827 |
| L middle frontal (9) | −44 | 17 | 29 | 4.19 | 253 |
| L superior temporal (38) | −48 | 12 | −22 | 3.98 | 257 |
| L amygdala | −32 | −9 | −21 | 4.90 | 1677 |
| R middle frontal (10) | 34 | 55 | 3 | 4.50 | 295 |
| R superior temporal (38) | 48 | 13 | −17 | 4.09 | 222 |
| R uncus | 26 | −5 | −23 | 5.17 | 4998 |
| Gray Matter Areas Related to Reduced Speech Fluency | |||||
| All FTLD | |||||
| L inferior frontal/superior temporal (44/22) | −57 | 7 | −5 | 4.18 | 154 |