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. 2011 Sep 30;39(22):e151. doi: 10.1093/nar/gkr773

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Average SHAPE reactivity (window size = 100 nt) as a function of nucleotide position. The HCV IRES has the lowest SHAPE reactivity. The region after the AUG start site is unstructured yet possesses a high density of codons whose third position is conserved. Codon 91, the putative site of internal core translation initiation is indicated, and represents the region with the second lowest SHAPE reactivity.