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. 2011 Oct 8;39(22):e155. doi: 10.1093/nar/gkr829

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — In vivo characterization of the theo-TetR intramer. (A) Nucleotide sequence and secondary structure of the theo-TetR intramer. The 5’- and 3’-stem region is identical to Figure 2A and, thus, denoted as black points. (B) Theo-TetR intramer-responsive reporter gene expression levels in the absence (blue column) and in the presence of 2 mM theophylline (red column). The rationally designed connection sequence has a strong influence on the performance of the device. (C) Specificity and cytotoxicity of the system. In contrast to theophylline, caffeine does not specifically repress SEAP expression. However, due to their cytotoxicity, both compounds reduce overall gene expression by 25%.