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. 2011 Sep 2;39(22):9620–9632. doi: 10.1093/nar/gkr674

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — UVA photoproducts in oligonucleotides containing S⁴TdR with a 5′G or C (A and B) The GS⁴TT duplex was irradiated with 10 kJ/m² UVA and analysed as described in the legend to Figure 6A and B. Eluted S⁴TdR (26 min) is shown as arrows. The A₃₃₅ scales in the two panels in A and the fluorescence (Ex 320; Em 370) scales in B are the same for both traces. (C) UVA dose-dependence of S⁴TdR destruction in the CS⁴TG and GS⁴TT duplexes. Residual S⁴TdR in digests of irradiated duplexes was quantified from A₃₃₅. Data for the TS⁴TG duplex are shown for comparison. (D) Detection by ELISA of photoproducts in UVA (10 kJ/m²) irradiated TS⁴TG and GS⁴TT duplexes. Inset: ELISA of DNA extracted from CCRF-CEM cells irradiated with 10 J/m² UVC.