Table 3.
Between-Group Differences in Functional Brain Activationa
| Variable | BA 10/46 | BA 8 | BA 6 |
|---|---|---|---|
| Whole brain | |||
| P value (FDR corrected) | .049 | .049 | .049 |
| Cluster size | 711 | 120 | 58 |
| F value | 8.20 | 5.90 | 5.74 |
| Peak cluster coordinatesb | −28, 28, 16 | −26, 16, 52 | −16, 2, 52 |
| Full cluster description | Left middle dorsolateral prefrontal gyrus extending into left inferior frontal gyrus | Left caudal lateral middle frontal gyrus | Left medial frontal gyrus |
| Contrast value | |||
| Chemotherapy group, mean (SD) (n=22) | 1.90 (3.0)H(1.20) | 2.96 (5.1)N(0.83),H(1.00) | .41 (2.1)H(1.00) |
| No-chemotherapy group, mean (SD) (n=18) | 3.72 (2.4)H(0.79) | 7.02 (4.7) | .97 (2.9)H(0.75) |
| Healthy control group, mean (SD) (n=17) | 6.42 (4.2) | 9.95 (8.5) | 3.38 (3.5) |
| F value | 8.74 | 6.48 | 5.87 |
| P value | .001 | .003 | .005 |
| d value | 1.10 | 0.97 | 0.92 |
Abbreviations: BA, Brodmann area; FDR, false discovery rate.
a
H Indicates significantly different from the healthy control group; N significantly different from the no-chemotherapy group. Effect size is shown in the superscript parenthesis for pairwise comparisons.
b
Per the Montreal Neurological Institute numbering system.