Table 4.
Outcome Measures and fMRI Task Performance Dataa
| Variable | Mean (SD)
|
F Value | P Value | ||
|---|---|---|---|---|---|
| Chemotherapy (n=25) | No Chemotherapy (n=19) | Healthy Control Individuals (n=18) | |||
| WCST:CV4 total errors | 46 (9.6) | 51 (10.2) | 49 (9.6) | 1.8 | .18 |
| WCST:CV4 perseverative errors | 4412H(0.83) | 51 (12) | 54 (12) | 4.6 | .02 |
| WCST:CV4 nonperseverative errors | 43 (7.4) | 47 (9.3) | 46 (7.6) | 0.99 | .38 |
| WCST:CV4 time, s | 313 (68)N(0.66),H(1.20) | 267 (71) | 246 (40) | 3.3 | .05 |
| Digit span | 11 (2.1) | 11 (2.2) | 11 (2.4) | 0.1 | .88 |
| Letter fluencyb | 12 (3.9) | 13 (3.7) | 14 (3.1) | 2.5 | .09 |
| BRIEF | 64 (13)N(0.96),H(1.20) | 52 (12) | 51 (9) | 8.5 | .001 |
| CAD | 50 (10) | 44 (12) | 47 (10) | 1.0 | .37 |
| fMRI task correct, % | 69 (12) | 70 (16) | 69 (17) | 0.1 | .92 |
| fMRI task reaction time, ms | 1370 (268) | 1324 (215) | 1371 (224) | 0.3 | .71 |
Abbreviations: BRIEF, Behavioral Rating Inventory of Executive Function; CAD, Clinical Assessment of Depression; fMRI, functional magnetic resonance imaging; WCST:CV4, Wisconsin Card Sorting Test Computer Version 4–Research Edition.
a
H Indicates significantly different from the healthy control group; N significantly different from the no-chemotherapy group. Effect size is shown in the superscript parentheses for significant pairwise comparisons.
b
Section of the verbal fluency subtest of the Delis-Kaplan Executive Function System.