Table 5.
Allele and genotype distributions for 22 genetic polymorphisms: all response-evaluable patients with genotype data.
| Gene | Poly-morphism | Major Allele (1) | Minor Allele (2) | HWE P-value |
Minor Allele Frequency (%) | Number of Patients (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype 11 | Genotype 12 | Genotype 22 | Genotype Unknown | Total | ||||||
| BTNL2 | rs2076530 | A | G | 0.31 | 41.4 | 24 (37.5) | 27 (42.2) | 13 (20.3) | 1 (1.5) | 65 (85.5) |
| CCR5 | CCR5d32 | wt | d32 | 0.49 | 10.0 | 53 (81.5) | 11 (16.9) | 1 (1.5) | 0 (0.0) | 65 (85.5) |
| CCR5 | rs1799987 | A | G | 0.30 | 39.2 | 26 (40.0) | 27 (41.5) | 12 (18.5) | 0 (0.0) | 65 (85.5) |
| CD86 | rs1129055 | G | A | 0.15 | 31.5 | 33 (50.8) | 23 (35.4) | 9 (13.8) | 0 (0.0) | 65 (85.5) |
| CD86 | rs2681417 | A | G | 1.00 | 2.4 | 60 (95.2) | 3 (4.8) | 0 (0.0) | 2 (3.1) | 65 (85.5) |
| CTLA4 | rs11571317 | C | T | 1.00 | 4.6 | 59 (90.8) | 6 (9.2) | 0 (0.0) | 0 (0.0) | 65 (85.5) |
| CTLA4 | rs1863800 | C | T | 0.79 | 37.3 | 24 (38.1) | 31 (49.2) | 8 (12.7) | 2 (3.1) | 65 (85.5) |
| CTLA4 | rs231775 | A | G | 0.19 | 39.8 | 26 (40.6) | 25 (39.1) | 13 (20.3) | 1 (1.5) | 65 (85.5) |
| CTLA4 | rs3087243 | G | A | 1.00 | 36.5 | 25 (39.7) | 30 (47.6) | 8 (12.7) | 2 (3.1) | 65 (85.5) |
| CTLA4 | rs4553808 | A | G | 0.30 | 23.4 | 39 (60.9) | 20 (31.2) | 5 (7.8) | 1 (1.5) | 65 (85.5) |
| IFNAR1 | rs2257167 | G | C | 0.75 | 26.2 | 36 (55.4) | 24 (36.9) | 5 (7.7) | 0 (0.0) | 65 (85.5) |
| IFNAR2 | rs7279064 | T | G | 0.01 | 34.6 | 23 (35.4) | 39 (60.0) | 3 (4.6) | 0 (0.0) | 65 (85.5) |
| IFNG | rs2069705 | T | C | 0.58 | 34.6 | 29 (44.6) | 27 (41.5) | 9 (13.8) | 0 (0.0) | 65 (85.5) |
| IFNG | rs2430561 | A | T | 0.80 | 46.9 | 17 (26.6) | 34 (53.1) | 13 (20.3) | 1 (1.5) | 65 (85.5) |
| IL23R | rs1004819 | C | T | 0.44 | 38.5 | 26 (40.0) | 28 (43.1) | 11 (16.9) | 0 (0.0) | 65 (85.5) |
| IL23R | rs11209026 | G | A | 1.00 | 7.7 | 55 (84.6) | 10 (15.4) | 0 (0.0) | 0 (0.0) | 65 (85.5) |
| IL23R | rs2201841 | T | C | 0.59 | 35.9 | 25 (39.1) | 32 (50.0) | 7 (10.9) | 1 (1.5) | 65 (85.5) |
| IL23R | rs7517847 | T | G | 0.43 | 39.8 | 25 (39.1) | 27 (42.2) | 12 (18.8) | 1 (1.5) | 65 (85.5) |
| NOD2 | rs2066844 | C | T | 1.00 | 1.5 | 63 (96.9) | 2 (3.1) | 0 (0.0) | 0 (0.0) | 65 (85.5) |
| NOD2 | rs2066845 | G | C | 1.00 | 1.6 | 62 (96.9) | 2 (3.1) | 0 (0.0) | 1 (1.5) | 65 (85.5) |
| NOD2 | rs5743293 | D | I | 1.00 | 2.3 | 62 (95.4) | 3 (4.6) | 0 (0.0) | 0 (0.0) | 65 (85.5) |
| PTPN22 | rs2476601 | G | A | 1.00 | 4.6 | 59 (90.8) | 6 (9.2) | 0 (0.0) | 0 (0.0) | 65 (85.5) |
11 = major-allele homozygote; 12 = heterozygote; 22 = minor-allele homozygote.
Denominator for Minor Allele Percent is number of known alleles in row.
Denominator for percents in columns "11", "12", and "22" is number of patients in row who have a known genotype.
Denominator for percents in column "Genotype Unknown" is total number of patients in row.
Denominator for percents in column "Total" is total number of patients with genotype data.
rs1799987 is also known as rs28897671; rs2430561 is also known as (+ 874A- > T); CCR5d32 = rs333.