Table 2.
Differences between RA patients with and without CV events according to ACP1 polymorphisms
| Change | Genotype, no. (frequency) | Minor allele, | Allele test | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | 1/2 | Samples Set | N | 1/1 | 1/2 | 2/2 | no. (frequency) | P-adj* | OR (95% CI)* |
| rs10167992 | C/T | RA with CV | 215 | 171 (0.826) | 35 (0.169) | 1 (0.005) | 37 (0.089) | 0.321 | 0.72 (0.38 to 1.37) |
| RA without CV | 965 | 768 (0.799) | 168 (0.175) | 13 (0.014) | 194 (0.102) | ||||
| rs11553742 | C/T | RA with CV | 221 | 200 (0.966) | 21 (0.101) | 0 (0.000) | 21 (0.048) | 0.012 | 2.62 (1.24 to 5.53) |
| RA without CV | 1,015 | 932 (0.970) | 78 (0.081) | 3 (0.003) | 84 (0.041) | ||||
| rs7576247 | A/G | RA with CV | 207 | 112 (0.541) | 76 (0.367) | 18 (0.087) | 112 (0.272) | 0.203 | 0.76 (0.50 to 1.16) |
| RA without CV | 961 | 498 (0.518) | 388 (0.404) | 75 (0.078) | 538 (0.280) | ||||
| rs3828329 | C/T | RA with CV | 221 | 88 (0.425) | 103 (0.498) | 28 (0.135) | 641 (0.319) | 0.079 | 1.38 (0.96 to 1.97) |
| RA without CV | 1,015 | 482 (0.502) | 403 (0.419) | 119 (0.124) | 159 (0.363) | ||||
CV, cardiovascular; RA, rheumatoid arthritis
* multiple regression adjusted by age at diagnosis of the disease, gender, shared epitope status and traditional CV risk factors, that is, hypertension, diabetes mellitus, dyslipidemia, obesity and smoking habit, as potential confounders.