Table 2.
Differences between rheumatoid arthritis patients with or without cardiovascular events according to CCR5Δ32 polymorphisma
RA patients, n (%) | ||||
---|---|---|---|---|
CCR5 genotype | With CV events | Without CV events | P value | OR (95% CI) |
CCR5/CCR5 | 84 (96.6) | 495 (88.7) | 1 | |
CCR5/CCR5Δ32 | 3 (3.4) | 61 (10.9) | 0.029 | 0.29 (0.06 to 0.92) |
CCR5Δ32/CCR5Δ32 | 0 (0.0) | 2 (0.4) | 0.99 | 0.0 (0.0 to 31.63) |
CCR5Δ32 carriers | 3 (3.4) | 63 (11.3) | 0.025 | 0.28 (0.06 to 0.89) |
Allele 2 | ||||
CCR5 | 171 (98.3) | 1,051 (94.2) | 1 | |
CCR5Δ32 | 3 (1.7) | 65 (5.8) | 0.024 | 0.28 (0.06 to 0.88) |
aCV: cardiovascular; OR (95% CI): odds ratio with 95% confidence interval; RA: rheumatoid arthritis.