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Optimized levels for central venous pressure, mean arterial pressure, and central venous oxygen saturation (ScvO2)
| Variable | Protocol |
|---|---|
| Central venous pressure | 8–12 mmHg (achieved by giving a 500 ml bolus of crystalloid every 30 min) |
| Mean arterial pressure | ≥ 65 ≤ 90 mmHg (if < 65 mmHg, give vasopressors; if > 90 mmHg, give vasodilators) |
| ScvO2 | If < 70%, transfuse with red cells to reach an hematocrit of ≥ 30% |
