Table 1.
Chemotactic activity of aminoacyl tRNA synthetases
| Leukocyte subpopulation | HisRS | MHRS | 1–48 HisRS | AsnRS | SerRS | AspRS | LysRS |
|---|---|---|---|---|---|---|---|
| Neutrophils | - | - | - | - | - | - | - |
| Monocytes | - | - | - | - | - | - | - |
| IL-2-activated monocytes | + | - | + | N.D. | N.D. | N.D. | N.D. |
| Lymphocytes | + | - | + | + | + | ± | ± |
| CD8 T cells | ± | - | ± | N.D. | N.D. | N.D. | N.D. |
| CD4 T cells | + | - | + | + | N.D. | N.D. | N.D. |
| iDCs | + | - | + | + | - | + | - |
| mDCs | - | - | - | - | N.D. | N.D. | N.D. |
-, absent response; +, positive response; ±, variable response; N.D., not done. AsnRS, asparaginyl tRNA synthetase; AspRS, aspartyl tRNA synthetase; HisRS, histidyl tRNA synthetase; iDC, immature dendritic cells; LysRS, lysyl tRNA synthetase; mDCs, mature dendritic cells; MHRS, mutated HisRS; SerRS, seryl tRNA synthetase.