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. 2011 Dec 15;7(12):e1002313. doi: 10.1371/journal.pcbi.1002313

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Adeniran et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(i) Steady state (1 Hz) action potentials for EPI (Ai), MIDDLE (Bi) and ENDO (Ci) cells using the full Markov chain I_hERG/I_Kr model. Thick lines represent WT and dashed lines represent N588K condition. (ii) Corresponding I_Kr current profiles for EPI (Aii), MIDDLE (Bii) and ENDO (Cii) cells. Thick lines represent WT and dashed lines represent N588K condition. (iii) Corresponding I-V relationships for EPI (Aiii), MIDDLE (Biii) and ENDO (Ciii) cells. Thick lines represent WT and dotted lines represent N588K condition. (D,E) I_Kr current amplitude for EPI (black bars), MIDDLE (grey bars) and ENDO (white bars) cells for all four I_hERG/I_Kr formulations for WT (D) and N588K (E) conditions (F) Computed APD difference between EPI and MIDDLE cells.