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. 2011 Dec 15;7(12):e1002313. doi: 10.1371/journal.pcbi.1002313

Figure 10. Snapshots of initiation and conduction of re-entry in a 2D idealised model of transmural ventricle.

Figure 10

(A) Schematic representation of the 2D model. (B) Measured minimal spatial length of a premature S2 stimulus that provides a sufficient substrate for the formation of a re-entrant circuit in WT and N588K for different EPI∶ MIDDLE∶ENDO IKr density ratios; 1.0∶1∶1, 1.5∶1∶1, 1.6∶1∶1 and 1.7∶1∶1. (C, D) Ci and Di: A planar conditioning wave generated by S1 stimulus at the ENDO end, which propagates towards the EPI end. Snapshots at time = 10 ms. Cii and Dii: S2 stimulus applied to the EPI part during the vulnerable window of the local tissue Ciii and Diii: Developed spiral wave from the S2 stimulus. Snapshots at time = 500 ms. Civ and Div: Snapshot of spiral wave at time = 1000 ms. Spiral wave self-terminated under the control condition before this recording point, but persisted under the SQT1 condition. Cv and Dv: Evolution of the action potential of a cell in the epicardial region for WT and N588K conditions.