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. 2011 Dec 15;7(12):e1002302. doi: 10.1371/journal.pcbi.1002302

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(A) Deviation from additivity for the folding landscapes (larger symbols), their scrambled versions (smaller symbols) and the two experimental landscapes. Error bars show one standard deviation within the ensemble of permuted landscapes. (B) Fraction of monotonic paths to the main peak in folding, scrambled and experimental landscapes. (C) The number of peaks is vastly greater in scrambled landscapes than in folding or experimental landscapes (with the exception of the sesquiterpene synthase landscape).