Table 1. Aromatic ring stacking and hydrophobic interactions (HIA) between Y652 and F656 side chains and hERG antagonists in WT and Y652A mutant channels.

Compound	WT			Y652A
	Y652	F656	∑ HIA	A652	F656	∑ HIA
Thioridazine	-	3 (t,p,e)	3	-	3 (t,p,e)	3
Bepridil	1 (p)	1 (e)	2	-	2 (e)	2
Propafenone	2 (t,e)	2 (t,e)	4	-	2 (e)	2
GPV0009	3 (t,2e)	1 (e)	4	-	1 (e)	1
Capsaicin	-	1 (p)	1	-	1 (e)	1
Cisapride	2 (p,e)	2 (t,p)	4	-	-	0
Dofetilide	2 (t,e)	2 (p,e)	4	-	1 (e)	1
E-4031	3 (t,2e)	2 (e)	5	-	2 (p,e)	2
Ibutilide	3 (e)	-	3	-	1 (p)	1
MK-499	1 (e)	1 (e)	2	-	-	0
Terfenadine	3 (t,2e)	2 (t,e)	5	-	1 (e)	1

(t = T-shaped stacking, p = parallel π-π-stacking, e = edge-to-edge interactions).