Table 2.
Using Independent HCC Studies to Validate HKU Gene Signature Identified at 0.05 Level
| HKU Gene Signature in Normal Tissue | ||
|---|---|---|
| Survival (7400 HKU Gene Signature) ‡ | ||
| Overlapping Genes | Enrichment p-value | |
| Japanese Gene Signature | 92 | 1.1E-9 |
| Chinese-Belgium Gene Signature | 133 | 3.1E-14 |
| Asia HCC Metastases Gene Signature | 144 | 2.0E-9 |
| Singapore Gene Signature | 19 | 2.4E-2 |
| Disease Free Survival (7661 HKU Gene Signature) | ||
| Overlapping Genes | Enrichment p-value | |
| Japanese Gene Signature | 96 | 1.8E-10 |
| Chinese-Belgium Gene Signature | 131 | 3.6E-12 |
| Asia HCC Metastases Gene Signature | 145 | 1.3E-8 |
| Singapore Gene Signature | 21 | 7.6E-3 |
| HKU Gene Signature in Tumor Tissue | ||
| Survival (5403 HKU Gene Signature) | ||
| Overlapping Genes | Enrichment p-value | |
| Japanese Gene Signature | 66 | 2.4E-6 |
| Chinese-Belgium Gene Signature | 142 | 5.5E-33 |
| Asia HCC Metastases Gene Signature | 97 | 1.2E-4 |
| Singapore Gene Signature | 19 | 4.9E-4 |
| Disease Free Survival (4377 HKU Gene Signature) | ||
| Overlapping Genes | Enrichment p-value | |
| Japanese Gene Signature | 58 | 9.1E-7 |
| Chinese-Belgium Gene Signature | 131 | 1.7E-35 |
| Asia HCC Metastases Gene Signature | 89 | 1.9E-6 |
| Singapore Gene Signature | 15 | 2.8E-3 |
‡We selected genes associated with survival or disease-free survival using nominal p-value of 0.05.