Table 1.
Mean peak, trough, or average scores/ratings (±SEM) of subjective, psychomotor, and physiological effects significantly affected by one or more of the active drug conditions.
| P value | Placebo | CARIS 350 | OXY 10 | CARIS 350/OXY 10 | |
|---|---|---|---|---|---|
| Subjective effects measures | |||||
| ARCI | |||||
| BGa,b (range: 0–13) | <0.001 | 4.5 (0.6) | 3.5 (0.5) | 2.6 (0.5)* | 2.0 (0.6)* |
| LSDb (range: 0–14) | <0.001 | 4.2 (0.6) | 4.2 (0.5) | 6.4 (0.8)* | 5.8 (0.7)* |
| PCAGb (range: 0–15) | <0.001 | 5.8 (0.9) | 7.1 (0.9) | 9.3 (0.8)* | 9.4 (0.7)* |
| Adjective rating scale (range: 0–4) | |||||
| Dry mouth | 0.003 | 0.4 (0.2) | 0.4 (0.2) | 1.3 (0.3)* | 0.9 (0.3) |
| Flushing | 0.002 | 0.1 (0.1) | 0.1 (0.1) | 0.9 (0.3)* | 0.5 (0.2) |
| Nodding | 0.005 | 0.1 (0.1) | 0.9 (0.3) | 1.2 (0.4) | 1.7 (0.4)* |
| Numb | 0.004 | 0.2 (0.1) | 0.1 (0.1) | 0.5 (0.2) | 0.9 (0.3)* |
| Skin itchy | <0.001 | 0 (0) | 0.1 (0.1) | 0.8 (0.2)* | 1.3 (0.3)* |
| VAS (range: 0–100) | |||||
| Coasting (‘spaced out’) | <0.001 | 15.3 (7.4) | 13.3 (5.9) | 28.5 (8.6) | 43.7 (9.8)* |
| Difficulty concentrating | 0.003 | 19.2 (7.7) | 26.5 (8.4) | 39.3 (10.5) | 48.5 (10.2)* |
| Dizzy | 0.01 | 7.3 (5.8) | 7.5 (6.1) | 22.6 (9.1)* | 18.7 (7.1) |
| Dreamy | <0.001 | 16.7 (7.9) | 16.0 (6.8) | 25.0 (7.8) | 43.9 (9.9)* |
| Floating | <0.001 | 7.4 (5.4) | 2.3 (1.1) | 19.3 (7.8) | 34.5 (9.2)* |
| Heavy, sluggish feeling | 0.009 | 19.5 (9.2) | 26.5 (8.4) | 37.7 (10.1) | 48.5 (10.3)* |
| High (drug ‘high’) | <0.001 | 4.7 (4.0) | 8.5 (6.1) | 25.2 (8.1)* | 36.9 (10.2)* |
| Lightheaded | 0.004 | 4.3 (1.9) | 2.3 (1.0) | 26.1 (8.5)* | 25.7 (8.4)* |
| Pleasant bodily sensations | 0.004 | 6.8 (4.5) | 6.7 (4.9) | 18.1 (5.7) | 23.7 (8.4)* |
| Pleasant thoughts | 0.009 | 20.1 (7.8) | 25.1 (6.8) | 48.5 (10.6)* | 30.9 (7.7) |
| Sedated (calm, tranquil) | 0.007 | 14.8 (6.3) | 21.9 (6.2) | 35.1 (7.6)* | 33.9 (8.0)* |
| Unpleasant bodily sensations | 0.01 | 10.0 (6.4) | 9.9 (6.8) | 22.5 (8.9)* | 16.7 (8.0) |
| Drug effect/Drug liking/Take againc | |||||
| Feel drug effect | <0.001 | 2.0 (0.2) | 2.5 (0.2) | 3.7 (0.2)* | 3.8 (0.2)* |
| Like drug | 0.02 | 58.1 (4.0) | 58.1 (2.8) | 66.4 (6.4) | 72.2 (5.4)* |
| Like druga | 0.006 | 47.2 (0.7) | 44.1 (1.5) | 34.7 (5.3)* | 33.7 (4.6)* |
| Take drug again | 0.03 | 60.3 (4.3) | 61.3 (3.6) | 68.0 (6.3) | 74.9 (5.4)* |
| Take drug againa | 0.01 | 53.1 (3.0) | 45.1 (2.1) | 37.1 (6.0)* | 36.1 (4.6)* |
| Post-session Sequelae Questionnaire (Range: 0–4) | |||||
| Nausea | 0.004 | 0.1 (0.1) | 0 (0) | 0.6 (0.3) | 0.9 (0.3)* |
| Psychomotor measures | |||||
| ART (msec)b | 0.01 | 332 (12) | 343 (14) | 343 (17) | 369 (18)* |
| DSST (# of symbols completed)a | 0.02 | 45.6 (2.0) | 41.9 (3.2) | 41.3 (2.6) | 37.6 (2.3)* |
| DSST (# of symbols correct)a | 0.01 | 45.3 (2.1) | 41.1 (3.3) | 41.1 (2.6) | 37.1 (2.4)* |
| LRT (# of statements completed)a,b,d | 0.008 | 17.8 (1.4) | 15.9 (1.2) | 15.6 (1.2) | 14.4 (1.2)* |
| LRT (# of statements correct)a,b,d | 0.009 | 15.6 (1.9) | 13.4 (1.4) | 13.2 (1.6) | 11.9 (1.5)* |
| Physiological measures | |||||
| Miosis (mm)a | <0.001 | 6.6 (0.3) | 6.5 (0.3) | 4.9 (0.4)* | 4.4 (0.4)* |
Abbreviations: CARIS 350, carisoprodol 350 mg; OXY 10, oxycodone 10 mg; CARIS 350/OXY 10, carisoprodol followed 60 min later by 10 mg oxycodone; ARCI, Addiction Research Center Inventory; BG, Benzedrine Group scale; LSD, Lysergic Acid Diethylamide scale; PCAG, Pentobarbital-Chlorpromazine-Alcohol Group scale; ART, auditory reaction time; DSST, Digit Symbol Substitution Test; EHC, eye-hand coordination test; LRT, logical reasoning test
p<0.05 compared with placebo
trough rating
data based on 14 subjects – one subject’s data not included because of missing data due to a file transfer error
Drug effect, range 1–5 in which 1=I feel no effect at all from the drug(s) and 5=I feel a very strong effect; Like drug, range, 0–100, 0=dislike a lot, 50=neutral, 100=like a lot; Take again, 0=definitely would not, 50=neutral (don’t care), 100=definitely would. Last measure refers to desire to take drug(s) again on another session if given the opportunity
the LRT is a 1-min computerized test that consists of true-false statements about the juxtaposition of the two letters A and B (e.g., A is preceded by B – true or false)