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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Mucosal Immunol. 2011 Sep 21;5(1):19–29. doi: 10.1038/mi.2011.38

FIG. 5. Cells derived from TLR4 mutant mice are hyporesponsive to stimulation with N. gonorrhoeae.

FIG. 5

(a) BMDM or (b) splenic mononuclear cells were derived from BALB/c and BALB/c-Lpsd mice as described in the text, and treated with the indicated agents. Supernatant was collected at 24 hours for (a) and at the indicated time points for (b), and assayed for TNF-α or IL-6 by ELISA. Pam2Cys, lipopeptide Pam2-Cys-Ser-Lys4; GC lys, N. gonorrhoeae FA1090 crude lysates. Significance was calculated using an unpaired t-test, with p values as follows: **, p<0.01; ***, p<0.001; NS, not significant; BD, below detection. These data are representative of two independent experiments.