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. Author manuscript; available in PMC: 2012 Dec 22.
Published in final edited form as: J Med Chem. 2011 Nov 28;54(24):8451–8460. doi: 10.1021/jm200982p

Figure 2. Aβ(39–42) selectively inhibits Aβ42-induced toxicity.

Figure 2

Aβ42 (10 μM) or staurosporine (ST, 0.2 μM) in the absence or presence of different Aβ(39–42) concentrations were A) incubated with differentiated PC-12 cells for 24 h and cell viability was determined using MTT assay; and B) incubated with differentiated PC-12 cells for 48 h and cell death was measured using LDH assay. C) α-synuclein (15 μM), alamethicin (4 μM), or Aβ42 (10 μM) in the absence or presence of different Aβ(39–42) concentrations were incubated with differentiated PC-12 cells for 24 h and viability was determined using MTT assay. The data represent mean ± SEM from at least three independent experiments with 5 replicates per data point (n ≥ 15).