Table 4.

Studies with detection rules defined by clinical need

Study	ADE/ADR prevalence considered
Nebeker et al, 200744	Two of the most common ADE types, delirium/psychosis and bleeding/anticoagulation problems, for which there were administrative data, were selected for detection.
Hartis et al, 200530	Baseline institutional data determined that reducing warfarin-related ADEs would give the greatest potential reduction in harm.
Huang et al, 200533	Increased reports of spironolactone-related life-threatening hyperkalemia motivated the implementation of a detection rule for this ADE type.
Bagheri et al, 200014	Detection rules for drug-induced liver injury were selected because liver damage was considered the most frequent type of ADR leading to drug withdrawal from the market.
Raschke et al, 199846	Detection rules targeted 37 drug- or drug class-specific ADEs that represent the most common ADE categories described in the Harvard Medical Practice Study.

ADE, adverse drug event; ADR, adverse drug reaction.