Figure 2.

Probability density function of the change in binding energy upon phosphorylation for interfacial Ser, Thr and Tyr (ΔΔΔG^p). Curves for homooligomers (N=74 phosphosites on interfaces where phosphate was attached) are shown in pink and for heterooligomers (N=104) in blue. Note that ΔΔG^p was calculated only for dimers due to limitations of the program. The distribution is shifted toward positive values (p-value =2e-16). Inset: permanent homooligomers are shown in red, strong transient homooligomers in orange and weak transient homooligomers in green. The distributions are smoothed by the Gaussian kernel density estimation.