Figure 4.

Phosphorylation in Smad1 and Smad2 complexes. A: superposition of Smad 2 structure (PDBID: 1khx, yellow) and phosphorylated model of Smad1 generated by FoldX (based on 1khu, each subunit are shown in red, green and blue, respectively). Phosphorylated Ser462, 463 and 465 are colored in red. B: C-terminal loops of three subunits of phosphorylated Smad 1 and Smad 2. Colors of subunits are the same as in A) and phosphate groups are depicted in the same color as subunits.