Table 2.

Summary of the impact of siRNAs to deplete eight proteins in SW480 and HT29 colorectal cancer cell lines treated with oxaliplatin (compared to EC50 of siRNA against GFP).

Gene Name	siRNA	Sequence of siRNA	Phenotype in SW480	Phenotype in HT29
FBL	a	CCGGAUGGUCUAGUCUAUGCA	Resistance	Sensitivity
	b	CCUCAUUAACUUGGCCAAGAA	No change	Sensitivity
	c	UUCAUUUGUCGAGGAAAGGAA	Resistance	Sensitivity
	d	CUGCGUAAUGGAGGACACUUU	Resistance	Sensitivity
FLJ20758	a	ACCAUUUAGAUUCAACAUUAA	Resistance	Sensitivity
	b	CAGGACAGAGAGAGUAAAUUA	Resistance	Sensitivity
	c	AACCAGUUAGCUGCUAUAUAA	Resistance	Sensitivity
	d	CCCAGGAAAUAGCCUAUUAAA	No change	No change
HNRPK	a	CAGCAAGUUUAUUAAUCAGAA	Resistance	Sensitivity
	b	CUCUAGUGUCUUAUUAGUUAA	No change	Sensitivity
	c	AUGGAAGUGACUAAUGCUGAA	Resistance	No change
	d	UUCCAUUGUAUGCAAAUUGAA	No change	No change
NONO	a	CCAAGUGGACCGCAACAUCAA	Sensitivity	Sensitivity
	b	CUGUGUUUGAUUUGUCUCAUA	No change	Sensitivity
	c	AGGCUUGACUAUUGACCUGAA	Sensitivity	Sensitivity
	d	AACAAACGUCGCCGAUACUAA	Sensitivity	Sensitivity
PABPC1	a	AAACGUAAUUUGGAUUAUAAA	No change	No change
	b	CGGGCUCGGAACACACAUUUA	Resistance	Sensitivity
	c	GACAAAUCCAUUGAUAAUAAA	No change	No change
	d	CCGCACCGUUCCACAGUAUAA	Resistance	Sensitivity
RALY	a	CUCAGCCAAGAUCAAGUUAAA	Sensitivity	Sensitivity
	b	CGGGCAGACCCUGGACAUCAA	No change	Sensitivity
	c	AAGCAAUGUAACCAACAAGAA	Sensitivity	Sensitivity
	d	CACCAUGUCCUUGAAGCUUCA	No change	Sensitivity
RPS7	a	CCGGCUAGUACGCGAAUUGGA	Resistance	Resistance
	b	CACGGGCAAGGAUGUUAAUUU	Resistance	Resistance
	c	CAGCCGGCUCAUAAAGGUUCA	Resistance	Resistance
	d	UUCGAGCGCCAAGAUCGUGAA	Resistance	Resistance
RPS8	a	UGGCUAUGUGCUAGAGGGCAA	Resistance	Resistance
	b	AUCGUGCUCAUCGACAGCACA	Resistance	Resistance
	c	CUCAGAGUGUUGUACUCGUAA	Resistance	Resistance
	d	AAGAGUUGGAGUUCUAUCUUA	Resistance	No change

Genes in bold indicate similar effects with at least two siRNA molecules in both cells lines.