Table 1.

Definition of intraepithelial neoplasia

	Definition
	Japanese view	Western view
Indefinite for intraepithelial neoplasia	A temporary term	A temporary term
	It is difficult to distinguish whether a lesion is neoplastic or non-neoplastic, or reactive or regenerative
LGIN	Characterized by a slightly modified mucosal architecture, including the presence of tubular structures with budding and branching, papillary enfolding, crypt lengthening with serration and cystic changes
HGIN	Characterized by an increasing architectural distortion with glandular crowding and prominent cellular atypia without stromal invasion
Adenocarcinoma/carcinoma	Diagnosed on nuclear and structural atypia, even when invasion is absent[45]	Diagnosed when evident invasive growth of neoplastic epithelium into the lamina propria of the mucosa or beyond is observed[46]

LGIN: Low-grade intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia.