Table 3.
Association* of microinfarcts and last ante-mortem measure of cognitive function, mediated by brain weight and AD lesions: the HAAS
| Microinfarcts | Total | Non Demented | Demented | |||
|---|---|---|---|---|---|---|
| β | p value | β | p value | β | p value | |
| Direct effects | ||||||
| 1. No mediators | −1.64 | <0.0001 | −1.03 | 0.003 | −0.56 | 0.10 |
| 2. Adjusted for mediators | −1.39 | <0.0001 | −0.85 | 0.01 | −0.70 | 0.03 |
| Proposed Mediators – Indirect effects | ||||||
| β | 90% CI | β | 90% CI | β | 90% CI | |
| 3. NP | −0.02 | (−0.08, 0.01) | −0.02 | (−0.10,0.05) | −0.002 | (−0.06,0.040) |
| 4. NFT | −0.03 | (−0.18, 0.10) | −0.0002 | (−0.04,0.05) | 0.13 | (0.015,0.30) |
| 5. Brain weight | −0.19 | (−0.30, −0.08) | −0.17 | (−0.30, −0.05) | 0.006 | (−0.11,0.15) |
| 6. Total Indirect effect | −0.24 | (−0.45, −0.05) | −0.19 | (−0.33, −0.03) | 0.14 | (−0.06,0.40) |
*
Adjusted for time from test to death, age at death, education, and, to control for total intracranial volume we adjusted for head circumference or estimated intracranial volume.