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Effect of disease on salivary flow. Total saliva was collected from mildly anesthetized 4-, 9-, 14-, and 18-week-old female MRL/lpr and MRL/+ mice. Secretion of saliva was stimulated by intraperitoneal injection of 0.20 mg isoproterenol plus 0.05 mg pilocarpine/100 g body weight and saliva was collected over a 10-minute period. Data are means ± SEM, n = 5 except for 18-week-old MRL/lpr where n = 3. *Significant difference in salivary flow between MRL/+ and MRL/lpr mice.
