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Effect of disease on acetylcholine release. Submandibular (top panels) and lacrimal glands (bottom panels) were removed from 18-week-old MRL/lpr and MRL/+ mice, and the release of acetylcholine was measured over a 20-minute period in buffer containing 5 mM KCl (spontaneous release) and 20 minutes in 75 mM KCl (evoked release). Data are means ± SEM, n = 3 to 5. *Significant difference from spontaneous release of acetylcholine.
