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. Author manuscript; available in PMC: 2012 May 19.
Published in final edited form as: Cell Host Microbe. 2011 May 19;9(5):390–403. doi: 10.1016/j.chom.2011.04.009

Figure 7. A colitis-enriched commensal Enterobacteriaceae isolate robustly colonizes antibiotic-pretreated dnKO mice without disease induction.

Figure 7

(A and B) Plot of serial fecal titers grown on BBE and MacConkey agar from antibiotic-pretreated dnKO mice (5–6 per group) gavaged with PBS, B. thetaiotaomicron (1×108 cfu/mouse), or Escherichia coli (2×108 cfu/mouse). Bacterial identity was determined by colony characteristics, confirmed by sequencing the 16S rRNA gene of representative colonies.

(C and D) Cecum and transverse colon pathology scores of mice described in Figures 7A and 7B displayed as individual (symbols) and median (bars) scores. Kruskall-Wallis test with post-hoc Dunn’s tests: (C) H2 = 11.49, p = 0.0032; (D) H2 = 12.02, p = 0.0025. All significant pairwise comparisons are displayed: *, p < 0.05; **, p < 0.01.

(E to H) Transverse colon and rectum crypt heights and crypt widths from mice described in Figures 7A and 7B displayed as mean +/− SEM. 1-way ANOVA with post-hoc Tukey’s test: (E) F2,14 = 2.580, p = 0.1112; (F) F2,14 = 5.434; p = 0.0179; (G) F2,14 = 6.438, p = 0.0104; (H) F2,14 = 7.268, p = 0.0068. All significant pairwise comparisons are displayed if omnibus p-value by ANOVA was significant: *, p < 0.05.

See also Figure S6.