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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Glia. 2011 Dec;59(12):1911–1922. doi: 10.1002/glia.21233

Figure 2. Ad-IRF3 modulates astrocyte inflammatory gene expression.

Figure 2

Astrocyte cultures were exposed to control Ad-GFP or Ad-IRF3 at 500 moi for 48 h, and then stimulated with IL-1β and IFNγ for 16 h. Q-PCR analysis was performed using PBDA as a control. Data were normalized to the level induced in control (Ad-GFP) culture and expressed as fold-induction in a log 10 scale (0.1 = no induction) for increased genes (A) or % inhibition for decreased genes (B). Percent (%) inhibition was calculated as 100 X [1 – Ad-IRF3/Ad-GFP]. Each symbol represents data generated using a different astrocyte case (n = 4 to 9) and the bar represents the mean value. Single sample t-test was performed to determine p value. * p < 0.05, ** p < 0.01, *** p < 0.001.