Table 1.

Clinical and laboratory manifestations of 53 haematological patients with Mycobacterium tuberculosis (TB) infection

	Total (n = 53)	Neutropenia			Sites of tuberculosis
		No (n = 27)	Yes (n = 26)	P value	Pulmonary TB only (n = 38)	Extra-pulmonary involvemente (n = 15)	P value
Elderly				0.28			0.24
Age more than 60 year	25	15	10		20	5
Age less than 60 year	28	12	16		18	10
Gender				0.56			0.34
Male	37	20	17		28	9
Female	16	7	9		10	6
Underlying Diabetes mellitus				0.67			0.66
Yes	6	4	2		5	1
No	47	23	24		33	14
Hematological Disease				0.013			0.76
Acute myeloid leukemia	29	10	19		20	9
Non-Acute myeloid leukemia	24	17	7		18	6
Diagnosis of tuberculosis and malignancy				0.001			0.33
Synchronousa	17	3	14		14	3
Non-synchronous	36	24	12		24	12
Allogeneic stem cell transplantation				0.19			> 0.99
Yes	6	5	1		4	2
No	47	25	22		34	13
Defeverence within 72 hoursb				0.55			0.030
Yes	17	9	8		15	2
No	31	13	18		18	13
Extra-pulmonary tuberculosis				> 0.99
Yes	38	19	19
No	15	8	7
Laboratory datac
Absolute neutrophil count (/uL) at fever	1970	3587	198	0.019	2174	1100	0.87
Absolute neutrophil count (/uL) at nadir	39	761	17	< 0.001	39	39	0.59
Albumin (g/dL)	3.60	3.48	3.70	0.40	3.50	3.6	0.80
Serum alanine aminotransferase (IU/L)	30	26	34	0.67	34	27	0.44
Alkaline phosphatase (IU/L)	174	207	141	0.06	175	153	0.52
Lactate dehydrogenase (IU/L)	509	574	440	0.96	509	509	0.58
C-reactive protein (mg/dL)	5.42	5.43	5.16	0.60	5.59	4.73	0.48
Treatmentd
Standard therapy	39	20	19	> 0.99	31	8	0.048
Fluoroquinolone based therapy	9	4	5		4	5
Outcome (30 days)
Death	3	1	2	0.61	0	3	0.019
Alive	50	26	24		38	12

^aSynchronous define as diagnosis of tuberculosis within 3 months of hematological malignancy

^bFive patients with pulmonary tuberculosis did not present with fever

^cMedian Value

^d48 patients received anti-tuberculosis treatment

^eFive of the 15 patients (33.3%) with extra-pulmonary tuberculosis (lymph node, 2; liver aspirates, 1; urine, 1; and blood, 1) also had documented pulmonary tuberculosis