Table 3.
Spearman Partial Correlations between MRI and Pathologic Characteristics (with significant correlations in bold type)
| All ROIs (n=48) | MTR | MD | FA | Axial Diffusivity | Radial Diffusivity |
|---|---|---|---|---|---|
| Myelin density | 0.63 (p<0.0001) | −0.58 (p<0.0001) | 0.38 (p=0.008) | −0.41 (p=0.004) | −0.52 (p=0.0002) |
| Axonal density | 0.58 (p<0.0001) | −0.53 (p=0.0002) | 0.42 (p=0.003) | −0.50 (p=0.0003) | −0.59 (p<0.0001) |
| Axonal area | −0.46 (p=0.001) | 0.47 (p=0.0008) | −0.41 (p=0.004) | 0.38 (p=0.008) | 0.46 (p=0.001) |
| MHC II (+) area | −0.14 (p=0.35) | −0.072 (p=0.63) | −0.17 (p=0.26) | −0.14 (p=0.33) | 0.16 (p=0.30) |
|
NAWM and sa
ROIs only (n=36) |
MTR | MD | FA | Axial Diffusivity | Radial Diffusivity |
| Myelin density | 0.16 (p=0.37) | −0.19 (p=0.28) | 0.14 (p=0.42) | −0.08 (p=0.66) | −0.25 (p=0.15) |
| Axonal density | 0.22 (p=0.21) | −0.32 (p=0.06) | 0.20 (p=0.24) | −0.25 (p=0.15) | −0.27 (p=0.11) |
| Axonal area | 0.06 (p=0.73) | 0.14 (p=0.43) | −0.23 (p=0.18) | −0.011 (p=0.95) | 0.08 (p=0.65) |
| MHC II (+) area | −0.19 (p=0.26) | −0.16 (p=0.36) | −0.33 (p=0.05) | −0.38 (p=0.03) | 0.12 (p=0.50) |
*
ROI = regions of interest; MTR = magnetization transfer ratio; MD = mean diffusivity; FA = fractional anisotropy