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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Int J Clin Rheumtol. 2011 Aug;6(4):423–439. doi: 10.2217/ijr.11.32

Figure 1. Three major epigenetic alterations seen among lupus patients.

Figure 1

(A) Increase in histone acetylation leading to local relaxation of chromatin structure, (B) hypomethylation of cytosines in cytosine–guanosine dinucleotides, leading to increased transcription of methylation-sensitive genes, and (C) alteration in post-transcriptional regulation of genes (including those involved in DNA methylation) at the tRNA level via increased miRNA expression and activation of the RISC.

Ac: Acetyl; Me: Methyl; RISC: RNA-induced silencing complex.