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. 2011 Nov 23;54(24):8328–8342. doi: 10.1021/jm2007326

Table 3. Inhibition of CHK1 and CHK2 by Imidazo[4,5-c]pyridines and Isoquinolines.

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a

IC50 determined in DELFIA.(33) Mean of two independent determinations; individual values in parentheses. Standard inhibitor staurosporine gave CHK1 IC50 = 2.1 (±1.8) nM and CHK2 IC50 = 27 (±8) nM.

b

LE = [−1.4 log10(IC50 (M))]/(number of heavy atoms).(34)

c

Not determined.

d

Mean (±SD) of at least three independent determinations.

e

Single determination.

f

Poor solubility gave variability for this analogue in this assay.