Table 1. TORC1, TORC2, and EGO complex orthologs in various genera.
| S. cerevisiae | S. pombe | C. albicans | D. discoideum | A. thaliana | C. elegans | D. melanogaster | Mammals |
|---|---|---|---|---|---|---|---|
| TORC1 | |||||||
| TOR1 or TOR2 | Tor1 or Tor2 | Tor1 | Tor | TOR | TOR/let-363 | TOR | mTOR |
| Kog1/Las24 | Mip1 | Kog1 | Raptor | RAPTOR1A and | daf-15 | Raptor | Raptor |
| RAPTOR1B | |||||||
| Lst8 | Wat1/Pop3 | Orf19.3862 | lst8? | AT2G22040 | lst-8? | CG3004 | mLST8 |
| AT3G18140 | |||||||
| Tco89 | Tco89 | Tco89 | pcr25kl1p3887 | — | — | — | — |
| — | Toc1 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | PRAS40 |
| — | — | — | — | — | — | — | DEPTOR |
| TORC2 | |||||||
| TOR2 | Tor1 or Tor2 | Tor1 | tor | TOR | TOR/let-363 | TOR | mTOR |
| Avo1 | Sin1 | orf19.5221 | piaA | sinh-1 | Sin1 | mSIN1 | |
| Avo2 | — | Avo2 | — | — | — | — | |
| Avo3/Tsc11 | Ste20 | Tsc11 | rip3 | rict-1 | Rictor | Rictor | |
| Lst8 | Wat1/Pop3 | Orf19.3862 | lst8 | AT2G22040 | lst-8 | CG3004 | mLST8 |
| AT3G18140 | |||||||
| Bit61 | Bit61 | — | — | — | — | — | PRR5/Protor |
| — | — | — | — | — | — | — | DEPTOR |
| EGO complex | |||||||
| Gtr1 | Gtr1 | Gtr1 | ragA | — | raga-1 | RagA | RagA,B |
| Gtr2 | Gtr2 | Gtr2 | ragC | — | ragc-1 | RagC | RagC,D |
| Ego1/Meh1/Gse2 | — | — | — | — | — | CG14184 | LAMTOR1/p18 |
| Ego3/Slm4/Nir1/Gse1 | — | — | — | — | lamtor-2, ? | CG5189, CG5110 | LAMTOR2/p14, LAMTOR3/ MP1 |
Orthologs listed are from Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans, Dictyostelium discoideum, Arabidopsis thaliana, Caenorhabditis elegans, Dictyostelium melanogaster, and mammals. P-POD: Princeton Protein Orthology Database/BLAST. We note that TORC2 appears to be absent in plants, e.g., A. thaliana. —, no demonstrated/obvious ortholog.