Figure 1 .

Identification of a domain of the foot as a conserved region of RNA pol II in eukaryotes. (A) Amino acid comparisons of Rpb1, Rpc160, Rpa190, and their homologs in archaea and bacteria. Amino acids were considered as conserved when they were present in at least half of the compared sequences. The following AG, ST, CS, DN, DE, EQ, MILV, KR, and FWY were grouped together. Highly conserved positions are shown in yellow. Species are indicated as follows: Sc (Saccharomyces cerevisiae), Sp (Schizosaccharomyces pombe), Hs (Homo sapiens), At (Arabidopsis thaliana), Mj (Methanococcus jannaschii), Ec (Escherichia coli), and Ta (Thermus aquaticus). The amino acid residue numbers indicated correspond to S. cerevisiae Rpb1 subunit. (B) Schematic view of the conserved region of the foot of the RNA pol II of S. cerevisiae on the structure of the RNA pol II. Blue and cyan: foot of RNA pol II where cyan corresponds to the conserved region of the foot. Magenta, Rpb5; green, Rpb8.