Table 4.
Adjusted odds ratios of willingness to participate in diet, hypertension, and cancer trialsa
| Covariates | OR for willingness to participate | |||||
|---|---|---|---|---|---|---|
| Diet Trial | Hypertension Trial |
Cancer Trial |
||||
| OR | (95% Cl) | OR | (95% Cl) | OR | (95% Cl) | |
| Race | ||||||
| White (ref) | ||||||
| African American | 0.8 | 0.5,1.1 | 0.8 | 0.6,1.3 | 0.8 | 0.5,1.2 |
| Gender | ||||||
| F (ref) | ||||||
| M | 0.7 | 0.5, 1.0 | 1.8 | 1.3,2.6 | 1.9 | 1.3,2.8 |
| Age | ||||||
| < 65 (ref) | ||||||
| 65–80 | 0.8 | 0.5,1.5 | 0.7 | 0.4,1.2 | N/Ac | N/Ac |
| ≥ 80 | 0.5 | 0.3,0.98 | 0.5 | 0.2,0.9 | ||
| Self rating of health | ||||||
| Excellent/Very Good/Good (ref) | ||||||
| Fair/Poor | 0.9 | 0.6,1.4 | 0.8 | 0.5,1.2 | 0.6 | 0.4,1.0 |
| History of target diseaseb | ||||||
| N (ref) | ||||||
| Y | 1.6 | 1.03,2.3 | 1.1 | 0.8,1.5 | 1.1 | 0.7,1.8 |
| Prior participation in clinical trial | ||||||
| No prior participation (ref) | ||||||
| Personal participation | 1.8 | 1.2,2.6 | 1.4 | 1.0,2.1 | 1.3 | 0.8,2.3 |
| Family/friend participation | 0.9 | 0.5,1.6 | 0.6 | 0.3,1.1 | 1.3 | 0.7,2.4 |
| Awareness of Tuskegee Syphilis Study | ||||||
| N (ref) | ||||||
| Y | 1.6 | 1.1,2.3 | 1.1 | 0.7,1.5 | 1.6 | 1.1,2.3 |
| Trust in PCP | ||||||
| 1st quartile (More trust) (ref) | ||||||
| 2nd quartile | 0.9 | 0.5,1.4 | 1.1 | 0.7,1.8 | 0.7 | 0.4,1.2 |
| 3rd quartile | 0.6 | 0.4,1.0 | 0.9 | 0.5,1.4 | 0.7 | 0.4,1.2 |
| 4th quartile (Least trust) | 0.5 | 0.3,0.8 | 0.6 | 0.3,0.9 | 0.6 | 0.4,1.0 |
| Distrust in clinical research | ||||||
| N (ref) | ||||||
| Y | 2.1 | 0.7,6.1 | 1.0 | 0.3,2.7 | 0.6 | 0.2,1.9 |
| Receiving money as payment for your time | ||||||
| Less Important (ref) | ||||||
| More Important | 1.2 | 0.9,1.8 | 1.6 | 1.1,2.3 | 1.8 | 1.2,2.7 |
| Your belief that you will personally benefit from participating in the clinical research trial | ||||||
| Less Important (ref) | ||||||
| More Important | N/Ac | N/Ac | 1.3 | 0.8,2.1 | 1.7 | 1.04,2.8 |
| Your belief that someone else in the future will benefit from your participation in the clinical research trial | ||||||
| Less Important (ref) | ||||||
| More Important | 2.1 | 0.8,5.3 | 3.9 | 1.1,13.8 | 2.9 | 0.8,10.5 |
| Members of the research team are from the same race as you are | ||||||
| Less Important (ref) | ||||||
| More important | N/Ac | N/Ac | N/Ac | N/Ac | 0.5 | 0.3,0.8 |
a
Models, adjusted for sociodemographics, health/functional status, patient trust in PCP and clinical research, exposure to clinical research, attitudes about clinical research, and perceived discrimination and awareness of the Tuskegee Syphilis Study.
b
Target diseases are obesity, hypertension, and cancer for diet, hypertension, and cancer trials, respectively.
c
N/A denotes those variables that were not significantly related to the outcome (p >0.05) in bivariable analysis and thus were not included in the multivariable model.