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Endocytotic uptake of DNA-Au NPs in HeLa cells is mediated by scavenger receptors. Treatment with agonists of scavenger receptors, fucoidan (A) and polyinosinic acid (poly I, B), prior to nanoparticle addition results in up to 60% inhibition of the cellular uptake of DNA-Au NPs. Pharmacological agents that inhibit other modes of cellular entry, such as bafilomycin A1 and methyl β-cytodextrin, did not inhibit nanoparticle uptake (C, D, Supporting Information, Figure 4).
