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. 2011 Sep 20;105(9):1253–1259. doi: 10.1038/bjc.2011.362

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Copyright © 2011 Cancer Research UK

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The CSC hypothesis and disease recurrence. CSCs are responsible for driving tumour growth. If CSCs rather than other malignant cells evade chemotherapy, then they can be responsible for re-establishing the tumour, clinically presenting as local recurrence or metastatic disease.