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. 2011 Aug 17;39(21):9316–9328. doi: 10.1093/nar/gkr652

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — ZFR-mediated site-specific transgene integration. Cartoon showing hypothetical ZFR-mediated integration of a transgenic construct into a genomic target site. The genomic site is recognized by a heterodimer of the magenta and orange ZFR subunits, whereas the site on the transgene DNA is recognized by a homodimer of the grey ZFR. The diagram on the right illustrates how, in this scenario, inappropriate on-site dimerization could lead to unproductive complexes.