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. 2011 Dec 16;6(12):e28962. doi: 10.1371/journal.pone.0028962

Table 2. Influence of different variables on the risk of developing pre-diabetes and diabetes mellitus — ordinal logistic model.

Variable Before adjustment After adjustment (Model one) After adjustment (Model two) After adjustment (Model three) After adjustment (Model four)
OR (95.0% CI) Sig OR (95.0% CI) Sig OR (95.0% CI) Sig OR (95.0% CI) Sig OR (95.0% CI) Sig
Age 0.981 (0.644–1.495) 0.929 0.752 (0.473–1.196) 0.228 0.791 (0.494–1.269) 0.331 0.786 (0.498–1.243) 0.303 0.821 (0.516–1.305) 0.403
Sex 0.872 (0.553–1.375) 0.556 0.792 (0.481–1.304) 0.359 1.056 (0.633–1.762) 0.835 0.814 (0.498–1.333) 0.414 1.094 (0.662–1.810) 0.725
Hypertension 1.952 (1.278–2.980) 0.002 1.741 (1.105–2.743) 0.017 1.930 (1.214–3.068) 0.005 1.725 (1.102–2.699) 0.017 1.848 (1.172–2.914) 0.008
WC 1.554 (1.012–2.384) 0.044 1.219 (0.761–1.954) 0.410 2.347 (1.433–3.845) 0.001 - - - -
WHR 2.513 (1.519–4.158) <0.001 - - - - - - - -
BMI 1.477 (0.974–2.241) 0.067 - - - - 1.062 (0.671–1.680) 0.797 1.966 (1.231–3.140) 0.005
TC 1.398 (0.855–2.284) 0.182 1.304 (0.766–2.219) 0.327 1.237 (0.721–2.123) 0.440 1.323 (0.775–2.260) 0.305 1.292 (0.752–2.220) 0.354
TG 1.514 (0.991–2.314) 0.055 1.101 (0.685–1.769) 0.691 1.515 (0.931–2.465) 0.094 1.095 (0.685–1.752) 0.704 1.549 (0.956–2.510) 0.076
Lower HDL-C 1.026 (0.492–2.138) 0.945 - - - - - - - -
Higher LDL-C 1.294 (0.492–3.403) 0.602 - - - - - - - -
Hyperinsulinemia 1.179 (0.734–1.893) 0.497 - - - - - - - -
HOMA-β index 3.574 (2.177–5.867) <0.001 - - 6.445 (3.567–11.643) <0.001 - - 6.035 (3.410–10.682) <0.001
HOMA-IR index 2.317 (1.323–3.452) 0.002 2.039 (1.179–3.524) 0.011 - - 2.113 (1.223–3.650) 0.007 - -
Hs-CRP 1.030 (1.052–2.686) 0.030 1.446 (0.871–2.403) 0.154 1.222 (0.729–2.050) 0.447 1.443 (0.879–2.368) 0.147 1.290 (0.779–2.134) 0.322
IgE 1.674 (1.039–2.698) 0.034 1.713 (1.031–2.846) 0.038 1.599 (0.955–2.679) 0.074 1.866 (1.128–3.087) 0.015 1.763 (1.058–2.937) 0.030
Chymase 1.387 (0.858–2.244) 0.182 1.214 (0.730–2.020) 0.241 1.431 (0.850–2.410) 0.178 1.122 (0.677–1.859) 0.655 1.218 (0.730–2.033) 0.449
Tryptase 1.283 (0.794–2.074) 0.309 1.357 (0.815–2.260) 0.454 1.210 (0.720–2.033) 0.472 1.238 (0.747–2.051) 0.407 1.071 (0.641–1.789) 0.795

OR: odds ratio; CI: confidence interval; WC: waist circumference; WHR: waist-to-hip ratio; BMI: body-mass index; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; HOMA: homeostatic model assessment; hs-CRP: high-sensitivity C-reactive protein; IgE: immunoglobulin E.